Hepatocellular Carcinoma Clinical Practice Toolkit

Original source summary

Hepatocellular Carcinoma Clinical Practice Toolkit Mark Moseley Mon, 10/12/2026 - 15:09 The AASLD Digital Toolkit for Hepatocellular Carcinoma (HCC) brings together practical, evidence-based resources to support clinicians at every stage of HCC care—from surveillance and diagnosis through staging and treatment selection. The below collection features guideline-based algorithms, risk calculators, and interactive tools designed for quick reference at the point of care, helping providers translate current practice guidance into everyday clinical decision-making. Whether you are managing surveillance in patients with cirrhosis, interpreting imaging findings, or navigating treatment options across the disease spectrum, this toolkit is intended to serve as a centralized, continually updated resource for the hepatology community. Screening / Surveillance Patients at high risk for HCC should be entered into a biannual surveillance program with US and AFP. Those with abnormal US , AFP levels or limited visualizatin warrant further workup Who Should Undergo HCC Surveillance? A list of specific population groups whose annual estimated HCC incidence exceeds the threshold to warrant HCC surveillance Singal AG, Llovet JM, Yarchoan M, et al. AASLD Practice Guidance on prevention, diagnosis, and treatment of hepatocellular carcinoma Hepatology. 2023;78(6):1922-1965. doi:10.1097/HEP.0000000000000466 Image Image PAGE-B calculator Validated HCC risk score for individuals with chronic hepatitis B on antiviral therapy PAGE-B Calculator LI-RADS Ultrasound The American College of Radiology's standardized system for reporting and interpreting the results of surveillance ultrasound examinations in at-risk populations for HCC LI-RADS US Recall Algorithm for HCC Surveillance Ultrasound Findings AASLD's recall algorithm for subsequent HCC surveillance or diagnostic testing, based on ultrasound visualization, presence of lesions, and AFP levels Singal AG, Llovet JM, Yarchoan M, et al. AASLD Pra

Verbatim from AASLD (liver)'s own feed — "Hepatocellular Carcinoma Clinical Practice Toolkit"