Research feed

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This review summarises that uterine sarcomas are distinct diseases, with doxorubicin plus trabectedin now a first-line option for advanced leiomyosarcoma.

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After a 2023 Plasmodium malariae outbreak in Khanh Hoa Province, Vietnam, that species has persisted alongside P. falciparum and P. vivax, shifting local malaria patterns.

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This perspective argues that reassortment within long-endemic Asian H5N1 lineages, not just point mutations, is an underrecognized driver of zoonotic spillover risk.

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Phase III trials now support adding immunotherapy around surgery for resectable head and neck squamous cell carcinoma.

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A clinical-urodynamic phenotyping framework can help distinguish the causes of female voiding disorders that look alike by symptoms alone.

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Newly arrived humanitarian migrants in Oklahoma carried substantial burdens of strongyloidiasis, lead exposure and latent TB that varied widely by country of origin.

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A single post-lactation dose of cabergoline reduced postpartum breast cancer in Brca1-mutant mice, and was associated with lower risk in women.

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Neoadjuvant stereotactic radiotherapy to inferior vena cava tumor thrombus before nephrectomy was tested as a feasible approach in renal cell carcinoma.

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KRAS and TP53 co-mutation marked the worst survival and chemoresistance in advanced or recurrent endometrial cancer in this small sequencing study.

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A cancer care navigation program shortened time from surgery to adjuvant radiotherapy in head and neck cancer without changing disease-free survival.

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Cancer cases among Japanese adults aged 85 and over rose more than four-fold from 1995 to 2020, with later-stage diagnosis and less aggressive treatment.

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An updated model using mean oesophagus dose and overall treatment time predicts acute oesophageal toxicity in lung radiotherapy and now supports proton therapy selection.

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Flattening/debulking, sectioning, staining and embedding are the slowest steps in Mohs frozen section processing.

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Experimentally infected alpacas developed mild but productive H5N1 clade 2.3.4.4b infection, with virus confined to the upper respiratory tract.

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Direct RAS inhibitors are now showing randomized survival benefit in previously treated metastatic pancreatic cancer.

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Desmoplastic small round cell tumour has no targeted therapy and poor survival, and a workshop prioritised candidate targets and called for international collaborative trials.

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Age over 80, obesity and a history of overactive bladder were linked to poorer clinician-reported outcomes after stress incontinence surgery.

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Machine-learning models predict amputation outcomes in peripheral artery disease well, but the evidence is low certainty and unvalidated.

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In stage I uterine serous carcinoma, adjuvant chemotherapy was associated with better survival when myometrial invasion was present but not when it was absent.

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Endoscopic vein harvest for leg bypass looked comparable to open harvest, with possible wound benefits, based on retrospective data.

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An endoscopic endonasal route can reach the medial temporomandibular joint region and was used to remove selected tumors in a small series.

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Among HPV16/18-vaccinated women, less frequent cervical screening was non-inferior to more intensive screening for detecting lesions linked to non-vaccine HPV types.

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Timing of surgery after neoadjuvant therapy for borderline resectable pancreatic cancer should weigh several dimensions, not imaging alone.

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Neoadjuvant nivolumab plus ipilimumab produced durable survival in localized MSI-high gastric or GEJ cancer.

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In a South African neonatal unit, late-onset sepsis was mostly Gram-positive (led by coagulase-negative staphylococci) but increasingly featured resistant Gram-negative organisms, especially in the smallest infants.

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ROR1 supports mantle cell lymphoma growth by driving cell cycle progression and nucleotide synthesis.

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Social factors such as insurance type, income and education were linked to delays in diagnosing and treating resected pancreatic cancer.

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A prospective study found that liver cirrhosis is associated with a distinct, severity-related pattern of altered cortisol metabolism (reduced cortisol-to-cortisone conversion and increased alternative steroid pathway activity) that is mechanistically different from true adrenal insufficiency.

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About one in four residents of a rural Argentine community had evidence of past hepatitis E infection, with rodent exposure possibly relevant.

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A genomic-surveillance-driven approach can guide building a phage library and cocktails against common carbapenem-resistant Klebsiella pneumoniae capsule types.