Neuroradiology
September 15, 2026 · via Europe PMC
Angioplasty and stenting of symptomatic intracranial atherosclerotic stenosis: a dual-center experience using NeuroSpeed balloon-catheter and CREDO heal stent.
Alsady TM, Aburub A, Dob O, Kemmling A, Almohammad M.
AI summary — for doctors, generated from the abstract only
NeuroSpeed balloon angioplasty with CREDO heal stenting for symptomatic intracranial stenosis or bailout during thrombectomy achieved 83% technical success with acceptable short-term complications.
What was studied
Retrospective dual-center series of 42 patients treated with NeuroSpeed balloon and fibrin-heparin-coated CREDO heal stent, split into elective ICAS (23) and bailout stenting (19).
Key findings
- Technical success 83%
- Median mRS improved from 2 to 0 (p = 0.005)
- Acute stent occlusion 10.5% in bailout group; delayed asymptomatic occlusion 8.7% in ICAS group; restenosis 10.5% in bailout
- Procedure-related ICH about 4-5% per group
Clinical relevance
This suggests feasibility of this device combination in selected ICAS and bailout cases, but small retrospective uncontrolled data cannot inform choice over medical therapy.
Who should care
Limitations
Small retrospective uncontrolled series with incomplete late imaging follow-up (30/42).
This stent system appears workable for intracranial stenosis, pending prospective data.
This is an AI-generated summary of the published abstract, not a clinical recommendation. It may not reflect the full text or subsequent updates — verify against the original source before acting on it.
Abstract
Background
Intracranial atherosclerotic stenosis (ICAS) remains a significant cause of recurrent ischemic strokes. While aggressive medical management is the mainstay of treatment, percutaneous transluminal angioplasty (PTA) and intracranial stenting (ICS) are increasingly used, especially in cases refractory to medical therapy or as a bailout during frustrating thrombectomy.
Objective
To evaluate the safety, technical feasibility, and short-term outcomes of NeuroSpeed balloon-catheter angioplasty and CREDO heal stent implantation in patients with symptomatic ICAS with and without large or medium vessel occlusion (LVO/MeVO).
Methods
This retrospective, dual-center study included 42 patients who underwent ICS using the NeuroSpeed balloon-catheter and fibrin-heparin coated CREDO heal stent. Patients were divided into two subgroups: ICAS (n = 23) and Bailout stenting (n = 19). Procedural success with a stenosis grade reduction to ≤ 50%, complication rates, and clinical outcomes were analyzed.
Results
Technical success was achieved in 83% of cases. Clinical improvement was significant between baseline and follow-up, with a reduction in the median modified Rankin Scale score from 2 to 0 (p = 0.005). Acute stent occlusion occurred in 2 of 19 patients (10.5%) in the bailout group. Late vascular follow-up imaging was available in 30 patients; two asymptomatic delayed stent occlusions occurred in the ICAS group (2/23, 8.7%) and two cases of in-stent restenosis in the bailout group (2/19, 10.5%). Procedure-related intracranial hemorrhage occurred in one patient in the ICAS group (1/23, 4.3%) and one patient in the bailout group (1/19, 5.3%). One access-site pseudoaneurysm (1/42, 2.4%) was observed.
Conclusion
NeuroSpeed/CREDO-based intracranial stenting appears to be a technically feasible treatment for high-grade ICAS and as a bailout during thrombectomy, with favorable short-term clinical outcomes and acceptable complication rates. Further prospective studies are warranted to assess long-term safety, efficacy, and durability.
DOI
10.1007/s00234-026-04181-8
PMID
42742684
Research metadata (titles, abstracts, authors, publication dates) is sourced from Europe PMC, which aggregates content from PubMed/MEDLINE, PubMed Central, and other providers under the U.S. National Library of Medicine (NLM/NCBI). NLM does not claim copyright on abstracts; the original journal publishers or authors may hold rights to the full articles. AI-generated summaries are derived only from the abstract, never the full text, and are always labeled as AI-generated.
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