AJNR. American journal of neuroradiology
October 1, 2026 · via Europe PMC
Fibrin-Heparin-Coated Intracranial Stents as Salvage Therapy in Pediatric Focal Cerebral Arteriopathy-Inflammatory Type.
Cagalj M, Schaper A, Brickmann C, Koppers M, Witton-Davies T, Mpotsaris A.
AI summary — for doctors, generated from the abstract only
Balloon angioplasty and fibrin-heparin-coated stents stabilized a 13-year-old with progressive stroke from inflammatory focal cerebral arteriopathy refractory to medical therapy.
What was studied
Case report of a 13-year-old boy with focal cerebral arteriopathy-inflammatory type, likely Mycoplasma-associated, treated with salvage intracranial stenting.
Key findings
- Deterioration despite antiplatelets, immunosuppression, antimicrobials and IA spasmolysis
- Angioplasty and CREDO heal-type coated stents achieved revascularization
- Sustained stent patency with persistent distal upper limb hemiparesis
Clinical relevance
This suggests intracranial stenting may be considered as salvage in refractory pediatric arteriopathy in specialized centers, but this is a single case.
Who should care
Limitations
Single case report without long-term data.
Stenting rescued one child with worsening inflammatory arteriopathy.
This is an AI-generated summary of the published abstract, not a clinical recommendation. It may not reflect the full text or subsequent updates — verify against the original source before acting on it.
Abstract
Arterial ischemic stroke (AIS) in children is frequently associated with underlying arteriopathy. We report a 13-year-old boy with progressive AIS due to focal cerebral arteriopathy inflammatory type (FCA-i). Despite initial medical therapy, including antiplatelet agents, immunosuppressive therapy, antimicrobial treatment, and intra-arterial spasmolysis, he experienced clinical and radiographic deterioration. Endovascular therapy with balloon angioplasty and fibrin-heparin-coated intracranial stents achieved successful revascularization and stabilization. Vessel wall MRI and elevated Mycoplasma pneumoniae antibodies supported the diagnosis of FCA-i. Follow-up demonstrated sustained stent patency and vascular improvement, with persistent distal upper extremity-predominant hemiparesis.
Arterial ischemic stroke (AIS) in children is frequently associated with underlying arteriopathy. We report a 13-year-old boy with progressive AIS due to focal cerebral arteriopathy inflammatory type (FCA-i). Despite initial medical therapy, including antiplatelet agents, immunosuppressive therapy, antimicrobial treatment, and intra-arterial spasmolysis, he experienced clinical and radiographic deterioration. Endovascular therapy with balloon angioplasty and fibrin-heparin-coated intracranial stents achieved successful revascularization and stabilization. Vessel wall MRI and elevated Mycoplasma pneumoniae antibodies supported the diagnosis of FCA-i. Follow-up demonstrated sustained stent patency and vascular improvement, with persistent distal upper extremity-predominant hemiparesis.
DOI
10.3174/ajnr.a9317
PMID
41887752
Research metadata (titles, abstracts, authors, publication dates) is sourced from Europe PMC, which aggregates content from PubMed/MEDLINE, PubMed Central, and other providers under the U.S. National Library of Medicine (NLM/NCBI). NLM does not claim copyright on abstracts; the original journal publishers or authors may hold rights to the full articles. AI-generated summaries are derived only from the abstract, never the full text, and are always labeled as AI-generated.
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