International journal of clinical practice
December 18, 2023 · via Europe PMC
Global, Regional, and National Burden of Ectopic Pregnancy: A 30-Year Observational Database Study.
Bo W, Qianyu Z, Mo L
AI summary — for doctors, generated from the abstract only
Age-standardized incidence, mortality, and DALY rates of ectopic pregnancy declined globally from 1990 to 2019, but burden remains concentrated in low-SDI regions.
What was studied
GBD 2019 analysis of ectopic pregnancy across 21 regions and 195 countries.
Key findings
- ASIR EAPC -1.14 (-1.29 to -0.98)
- Death rate EAPC -0.9; DALY rate EAPC -0.83
- Absolute cases, deaths, and DALYs increased
- Low and low-middle SDI regions carried most burden
Clinical relevance
This highlights global inequities in ectopic pregnancy outcomes, supporting improved access to early diagnosis and treatment in low-resource settings.
Who should care
Limitations
Modeled GBD estimates subject to data quality limitations.
Ectopic pregnancy deaths are falling globally but remain high in poorer countries.
This is an AI-generated summary of the published abstract, not a clinical recommendation. It may not reflect the full text or subsequent updates — verify against the original source before acting on it.
Abstract
OBJECTIVE
To estimate global, regional, and national trends due to ectopic pregnancy as part of the 2019 Global Burden of Disease study.
METHODS
We systematically reviewed trends in ectopic pregnancy burden using data from the Global Burden of Disease (GBD) database, including 21 regions, 195 countries, and territories over the past 30 years. The trends of ectopic pregnancy-related incidence, mortality, and disability-adjusted life years (DALYs) attributable to all known risk factors were also analyzed. Age-standardized rates (ASRs) and their estimated annual percentage changes (EAPCs) were also calculated.
RESULTS
Incident cases, deaths, and DALYs of ectopic pregnancy increased worldwide in the past 30 years. The age-standardized incidence rate (ASIR) was decreasing (EAPC = -1.14, 95% confidence interval (CI): -1.29 to -0.98), and the age-standardized death (EAPC = -0.9, 95% CI: -1.03 to -0.76) and DALY rate decreased generally (EAPC = -0.83, 95% CI: -0.98 to -0.68). In addition, the burden of ectopic pregnancy is lower in areas with higher socioeconomic development, and significant positive correlations between ASRs and sociodemographic index (SDI) were observed, especially among low-middle SDI, and low SDI quintiles carried the majority burden of ectopic pregnancy.
CONCLUSION
Globally, the incidence, mortality, and DALY rate of ectopic pregnancy had been decreasing from 1990 to 2019. Compared with lower and decreasing ASIR in the high SDI region, ASIR in the low SDI region was always high, indicating the need for ectopic pregnancy treatment improvement and the establishment of more targeted and specific strategies in low SDI countries to reduce the incidence of ectopic pregnancy.
DOI
10.1155/2023/3927337
PMID
38146347
PMCID
PMC10749725
Research metadata (titles, abstracts, authors, publication dates) is sourced from Europe PMC, which aggregates content from PubMed/MEDLINE, PubMed Central, and other providers under the U.S. National Library of Medicine (NLM/NCBI). NLM does not claim copyright on abstracts; the original journal publishers or authors may hold rights to the full articles. AI-generated summaries are derived only from the abstract, never the full text, and are always labeled as AI-generated.
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