Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions
September 13, 2026 · via Europe PMC
The Incidence, Severity and Clinical Consequence of Left Pulmonary Artery Stenosis After PDA Device Closure in Premature Infants Less Than 2 Kilograms.
Mosher B, Wolschendorf R, Boyer P, Lu JC, Lowery R, Yu S, Duimstra A, Zampi JD.
AI summary — for doctors, generated from the abstract only
In a single-center study of premature infants under 2 kg undergoing transcatheter PDA closure, left pulmonary artery stenosis was common but typically mild and resolved over time, suggesting its occurrence should not discourage this treatment approach in this high-risk population.
What was studied
A retrospective single-center cohort study of 116 premature infants under 2 kg undergoing transcatheter patent ductus arteriosus device closure, assessing incidence, severity, anatomic risk factors, and clinical impact of left pulmonary artery stenosis.
Key findings
- Left pulmonary artery stenosis occurred in 37% (43/116) within 1 day post-procedure, though none had severe stenosis precluding device placement.
- At a median follow-up of 7.9 months, stenosis improved in nearly all patients; only 1 patient developed late, severe stenosis related to device embolization.
- Stenosis was not associated with patient or procedural factors and was not associated with worse pulmonary artery growth.
Clinical relevance
This suggests left pulmonary artery stenosis is a common but usually self-resolving complication after transcatheter PDA closure in premature infants, which should reassure clinicians that this complication's occurrence does not preclude proceeding with device closure in this vulnerable population, though continued monitoring remains warranted.
Who should care
Limitations
This was a single-center retrospective study; follow-up duration was relatively short, median 7.9 months, so very long-term outcomes are not captured.
Narrowing of the left pulmonary artery after closing a heart defect in very premature babies is common but usually mild and resolves on its own, suggesting this risk should not discourage using this treatment in these fragile infants.
This is an AI-generated summary of the published abstract, not a clinical recommendation. It may not reflect the full text or subsequent updates — verify against the original source before acting on it.
Abstract
Background
Transcatheter patent ductus arteriosus (PDA) device closure is an effective treatment option for premature infants with hemodynamically significant PDA. Left pulmonary artery (LPA) stenosis has been reported as a complication, however there is limited data on risk factors, clinical significance, and long-term outcomes. We aim to determine the incidence of LPA stenosis after transcatheter PDA closure in premature infants, describe anatomic factors associated with LPA stenosis, and evaluate the impact of LPA stenosis on pulmonary artery growth and re-interventions over time.
Methods
Single center retrospective cohort study of 116 premature infants who underwent transcatheter PDA closure while less than 2 kg. Clinical, angiographic and serial echocardiographic data were collected to determine the presence, severity, and clinical impact of LPA stenosis. Patient factors associated with the occurrence of LPA stenosis were evaluated using standard descriptive statistics.
Results
LPA stenosis occurred in 43 of 116 patients (37%) within 1 day post-procedure, though none had severe stenosis precluding device placement. At the most recent follow-up (median 7.9 months), the degree of LPA stenosis improved in nearly all patients. Only one patient developed late, severe LPA stenosis related to device embolization post-procedure. LPA stenosis was not associated with patient or procedural factors, and the presence of LPA stenosis was not associated with worse LPA growth.
Conclusion
LPA stenosis is common after PDA device closure in premature infants but was infrequently associated with persistent obstruction or the need for intervention during the available follow-up period. Most cases resolved over time without adverse impact, suggesting that its presence should not preclude device closure in this high-risk group.
DOI
10.1002/ccd.70849
PMID
42733222
Research metadata (titles, abstracts, authors, publication dates) is sourced from Europe PMC, which aggregates content from PubMed/MEDLINE, PubMed Central, and other providers under the U.S. National Library of Medicine (NLM/NCBI). NLM does not claim copyright on abstracts; the original journal publishers or authors may hold rights to the full articles. AI-generated summaries are derived only from the abstract, never the full text, and are always labeled as AI-generated.
Want more like this?
Browse more from the feed. A free account unlocks the full feed, saving and communities.
Back to the research feed