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Indian journal of nephrology

August 14, 2024 · via Europe PMC

Hypothyroidism Related Kidney Disease - A Report of Two Cases.

Jaryal A, Vikrant S, Sharma A.

Case ReportsOpen access

AI summary — for doctors, generated from the abstract only

A report of two cases illustrates that hypothyroidism can contribute to kidney dysfunction, with renal function improving after thyroid hormone replacement treatment.

What was studied

This case report describes two patients in whom hypothyroidism was identified as a contributing cause of renal dysfunction, and documents improvement in kidney function following treatment of the underlying hypothyroidism.

Key findings

  • In both reported cases, hypothyroidism was identified as a contributing factor to kidney dysfunction.
  • Treatment of hypothyroidism led to improvement in renal function in both patients, though specific laboratory values (e.g., creatinine or eGFR changes) are not given in the available abstract text.
  • Not reported in the abstract: specific patient demographics, severity of hypothyroidism, or timeline of renal function improvement are not detailed.
  • The report references prior literature, including case reports and some epidemiological studies, linking hypothyroidism to abnormalities in renal function parameters.

Clinical relevance

The findings suggest that hypothyroidism should be considered as a potentially reversible contributing cause of renal dysfunction in appropriate clinical contexts, supporting thyroid function testing in patients with otherwise unexplained kidney function changes. As a 2-patient case report, this cannot establish how common or significant this relationship is in the broader population.

Who should care

NephrologyPediatric Nephrology

Limitations

This is a report of only two cases with no control group, severely limiting generalizability; important clinical details (lab values, timelines) are not reported in the available abstract text.

Two case reports illustrate that hypothyroidism can contribute to kidney dysfunction, which improved after thyroid hormone treatment, supporting consideration of thyroid status in unexplained renal dysfunction.

This is an AI-generated summary of the published abstract, not a clinical recommendation. It may not reflect the full text or subsequent updates — verify against the original source before acting on it.

Abstract

Dysthyroid state affects kidneys in multiple ways. Hypothyroidism has been described as a cause of renal dysfunction in case reports, and a few large-scale epidemiological studies have shown association of hypothyroidism with abnormalities of renal function parameters. Restoration and improvement in renal functions have also been reported with treatment of hypothyroidism. We highlight two cases where hypothyroidism contributed to renal dysfunction and the treatment of hypothyroidism led to improvement in renal function.

DOI

10.25259/ijn_266_2024

PMID

40896635

PMCID

PMC12392224

Research metadata (titles, abstracts, authors, publication dates) is sourced from Europe PMC, which aggregates content from PubMed/MEDLINE, PubMed Central, and other providers under the U.S. National Library of Medicine (NLM/NCBI). NLM does not claim copyright on abstracts; the original journal publishers or authors may hold rights to the full articles. AI-generated summaries are derived only from the abstract, never the full text, and are always labeled as AI-generated.

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