Indian journal of pathology & microbiology
September 3, 2026 · via Europe PMC
Meissnerian neurofibroma: A rare histological variant of neurofibroma.
Hasan Z, Mandal S, Shrivastava P, Agrawal A, Tiwari A.
AI summary — for doctors, generated from the abstract only
This case report describes an extremely rare histological variant of neurofibroma with prominent Meissnerian (pseudo-meissnerian body) differentiation in a young woman, a benign tumor that is curative with complete excision.
What was studied
A single case report of a 26-year-old woman with a neurofibroma showing prominent Meissnerian differentiation (pseudo-meissnerian bodies), an extremely rare histological variant with fewer than ten previously reported cases.
Key findings
- The case demonstrated prominent, rather than the usual focal or sparse, pseudo-meissnerian body differentiation within a neurofibroma.
- Fewer than ten prior cases with this degree of Meissnerian differentiation have been reported in the literature.
- Pseudo-meissnerian bodies are also described, usually focally, in other peripheral nerve sheath tumors (e.g., schwannomas) and in congenital melanocytic nevi and neural crest hamartomas.
Clinical relevance
The findings suggest awareness of this rare variant can help pathologists correctly recognize it as a benign neurofibroma subtype rather than mistaking it for another entity, and that complete excision is considered curative.
Who should care
Limitations
This is a single case report, so findings cannot be generalized, and there is no comparative or outcome data beyond the stated curative excision.
A very rare neurofibroma variant with prominent Meissnerian differentiation was diagnosed in a young woman and is considered curable with complete surgical excision.
This is an AI-generated summary of the published abstract, not a clinical recommendation. It may not reflect the full text or subsequent updates — verify against the original source before acting on it.
Abstract
Abstract
Meissnerian neurofibroma is an extremely rare histological variant of neurofibroma, with less than ten reported cases of prominent differentiation toward pseudo-meissnerian bodies in the literature. The presence of focal or sparsely scattered pseudo-meissnerian bodies in neurofibromas is well documented in diffuse and plexiform types. It is also seen in various peripheral nerve sheath tumors, including schwannomas, as well as in congenital melanocytic nevi and neural crest hamartomas. The complete excision of the lesion is considered to be curative. We hereby present a rare case of prominent meissnerian differentiation in neurofibroma in a 26-year-old female.
DOI
10.4103/ijpm.ijpm_825_25
PMID
42696619
Research metadata (titles, abstracts, authors, publication dates) is sourced from Europe PMC, which aggregates content from PubMed/MEDLINE, PubMed Central, and other providers under the U.S. National Library of Medicine (NLM/NCBI). NLM does not claim copyright on abstracts; the original journal publishers or authors may hold rights to the full articles. AI-generated summaries are derived only from the abstract, never the full text, and are always labeled as AI-generated.
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