Thyroid : official journal of the American Thyroid Association
July 29, 2026 · via Europe PMC
Graves' Orbitopathy and Anophthalmia.
Pérez-López M, Perros P.
AI summary — for doctors, generated from the abstract only
In four patients with Graves' orbitopathy and prior unilateral anophthalmia, the anophthalmic orbit showed clinical and radiological GO with symmetric muscle involvement.
What was studied
Case series of four patients with Graves' orbitopathy and previously acquired anophthalmia in one eye.
Key findings
- Anophthalmic eye showed clinical and radiological GO in all cases
- Optic nerve compression in two patients
- Extraocular muscle involvement radiologically symmetrical between orbits
Clinical relevance
This highlights the need to recognize and manage GO in anophthalmic patients, particularly to protect vision in the remaining eye.
Who should care
Limitations
Four cases only; descriptive.
Graves' orbitopathy can affect an orbit without an eye, and the remaining eye needs vigilant protection.
This is an AI-generated summary of the published abstract, not a clinical recommendation. It may not reflect the full text or subsequent updates — verify against the original source before acting on it.
Abstract
Background
Graves' orbitopathy (GO) affects approximately 0.1% of the population. GO in anophthalmic patients is extremely rare and may provide insights into the pathogenesis of this disease.
Methods
We describe four cases of GO in patients with previously acquired anophthalmia in one eye.
Results
In all cases, the anophthalmic eye showed both clinical and radiological evidence of GO. In two patients, optic nerve compression was present. In all cases, involvement of extraocular muscles was radiologically symmetrical when comparing the two orbits.
Conclusions
GO in anophthalmic patients is a rare combination of ocular morbidities. Early recognition and appropriate management of GO in such patients are important if visual function is to be preserved. Whether anophthalmia predisposes to GO in susceptible patients is unclear. This rare group of patients may provide unique opportunities for studying the pathogenetic mechanisms in GO.
DOI
10.1177/10507256261473411
PMID
42522663
Research metadata (titles, abstracts, authors, publication dates) is sourced from Europe PMC, which aggregates content from PubMed/MEDLINE, PubMed Central, and other providers under the U.S. National Library of Medicine (NLM/NCBI). NLM does not claim copyright on abstracts; the original journal publishers or authors may hold rights to the full articles. AI-generated summaries are derived only from the abstract, never the full text, and are always labeled as AI-generated.
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