Resuscitation plus
August 25, 2026 · via Europe PMC
Neurofilament light chain for assessment of brain injury in four porcine cardiac arrest models.
Persson O, Frigyesi A, Valerianova A, +13 more, Friberg H.
AI summary — for doctors, generated from the abstract only
Across four porcine cardiac arrest models, plasma neurofilament light rose consistently after ROSC and correlated with no-flow duration.
What was studied
A multi-laboratory study of 44 pigs resuscitated from cardiac arrest in four models, with NfL measured before arrest and at 4 and 24 hours post-ROSC.
Key findings
- NfL changed significantly over time.
- 24-h NfL associated with no-flow duration (p=0.034, p=0.041).
- No significant association with functional outcomes in 26 animals (underpowered).
Clinical relevance
This supports NfL as a translational biomarker of brain injury in animal models; it has no immediate clinical application.
Who should care
Limitations
Animal models with heterogeneous protocols; functional outcome analyses underpowered.
Neurofilament light tracks brain injury in pig cardiac arrest models.
This is an AI-generated summary of the published abstract, not a clinical recommendation. It may not reflect the full text or subsequent updates — verify against the original source before acting on it.
Abstract
Background
Anoxic brain injury is the leading cause of death following successful resuscitation after out-of-hospital cardiac arrest. No experimental neuroprotective therapy has translated into clinical benefit. Collaborative efforts to harmonize methods may be essential for translational success. Neurofilament light chain (NfL) is a biomarker of neuroaxonal injury with emerging use in clinical practice, but data on its robustness and association with outcomes in porcine models is limited. Our aim was to use NfL as a quantitative marker to compare brain injury severity in different porcine cardiac arrest models.
Methods
Forty-four pigs (Sus scrofa domestica) were resuscitated after cardiac arrest in different experimental models in four laboratories. Plasma samples were collected prior to the arrest and at 4 and 24 h after return of spontaneous circulation. NfL concentration was measured using a Single molecule array (Simoa) immunoassay.
Results
NfL levels changed significantly over time (p n = 43) in both correlation and univariate regression analyses (p = 0.034, p = 0.041), while no significant associations were found with functional outcomes (n = 26) (p = 0.32, p = 0.20).
Conclusion
NfL increased consistently across four porcine cardiac arrest models, and higher 24-h NfL levels were associated with longer no-flow duration, supporting its robustness as a biomarker of neuroaxonal injury. Larger studies are needed to clarify its relationship with functional outcome, as the exploratory analyses were underpowered.
DOI
10.1016/j.resplu.2026.101466
PMID
42724964
PMCID
PMC13559832
Research metadata (titles, abstracts, authors, publication dates) is sourced from Europe PMC, which aggregates content from PubMed/MEDLINE, PubMed Central, and other providers under the U.S. National Library of Medicine (NLM/NCBI). NLM does not claim copyright on abstracts; the original journal publishers or authors may hold rights to the full articles. AI-generated summaries are derived only from the abstract, never the full text, and are always labeled as AI-generated.
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