The journal of obstetrics and gynaecology research
September 1, 2026 Ā· via Europe PMC
Association Between Isolated Maternal Hypothyroxinemia and Adverse Maternal and Infant Outcomes.
Zhang W, Liu S, Zheng J, Wang W, Ding X.
AI summary ā for doctors, generated from the abstract only
A meta-analysis of 22 cohort studies found isolated maternal hypothyroxinemia in about 5.7% of pregnancies and associated it with modestly higher risks of several complications.
What was studied
A systematic review and meta-analysis of 22 cohort studies on the prevalence of isolated maternal hypothyroxinemia and its association with pregnancy complications.
Key findings
- Pooled IMH prevalence 5.7% (95% CI 3.5-8.4%)
- Associated with higher GDM (estimate 1.12, 95% CI 1.01-1.24), macrosomia (1.41), preterm birth (1.26), and preeclampsia/eclampsia (1.26)
- The abstract labels these effect estimates as percentages; the exact measure type is unclear
Clinical relevance
Suggests IMH may be a marker of elevated pregnancy risk, though observational data cannot establish causation or treatment benefit.
Who should care
Limitations
Observational cohort studies only; reporting of effect measures in the abstract is unclear.
Isolated maternal hypothyroxinemia was associated with modestly higher pregnancy complication risks.
This is an AI-generated summary of the published abstract, not a clinical recommendation. It may not reflect the full text or subsequent updates ā verify against the original source before acting on it.
Abstract
Aim
The current meta-analysis aims to assess the incidence of isolated maternal hypothyroxinemia (IMH) and its impact on pregnancy complications and adverse pregnancy outcomes.
Methods
PubMed, Embase, Web of Science, and Cochrane databases were searched until November 15, 2024. Cochrane, a risk-of-bias assessment tool, was used to evaluate the quality of literature; R Studio and Stata 15.0 were employed for data analysis and publication bias assessment.
Results
In total, 22 cohort studies were analyzed, with a sample size of 33,1640 cases, including 16ā390 IMH patients. The meta-analysis revealed that the prevalence of IMH was 5.7% (95% CI: 3.5, 8.4%). Compared to pregnant women with normal thyroid function, the prevalence of gestational diabetes mellitus (GDM) in IMH patients was 1.12% (95% CI: 1.01,1.24), macrosomia was 1.41% (95% CI: 1.12, 1.65), preterm birth was 1.26% (95% CI: 1.12, 1.41), and preeclampsia/eclampsia was 1.26% (95% CI: 1.12, 1.41) (pā<ā0.05).
Conclusions
Patients with IMH have an elevated risk of GDM, preeclampsia, eclampsia, preterm birth, and macrosomia relative to normal pregnant women. It is anticipated that future studies will further confirm the complications related to pregnancy in patients with IMH.
DOI
10.1111/jog.70488
PMID
42706499
PMCID
PMC13550101
Research metadata (titles, abstracts, authors, publication dates) is sourced from Europe PMC, which aggregates content from PubMed/MEDLINE, PubMed Central, and other providers under the U.S. National Library of Medicine (NLM/NCBI). NLM does not claim copyright on abstracts; the original journal publishers or authors may hold rights to the full articles. AI-generated summaries are derived only from the abstract, never the full text, and are always labeled as AI-generated.
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