Journal of human reproductive sciences
October 1, 2025 · via Europe PMC
Changing Profile of the PCOS Women: A 15 Year Retrospective Cohort Study.
Kar S.
AI summary — for doctors, generated from the abstract only
Over 15 years at one Indian centre, women diagnosed with PCOS showed a worsening metabolic and phenotypic profile, including rising BMI.
What was studied
A retrospective chart review of 1,530 women with Rotterdam-defined PCOS at a tertiary centre in Odisha, India, comparing anthropometric, biochemical and ultrasound features across 2009-2013, 2014-2018 and 2019-2024.
Key findings
- Mean BMI increased from 26.40 to 28.42 kg/m2 between the first and third periods
- Other metabolic and phenotypic changes reported as significant; specific statistic not fully captured in the abstract
Clinical relevance
The trend may support attention to metabolic risk factors in women with PCOS in this population, though single-centre referral patterns could influence the findings.
Who should care
Limitations
Retrospective single private-centre data; changes in referral or diagnostic practice over time may confound trends; most results truncated in the abstract.
PCOS in this Indian population appears to be becoming more metabolically severe.
This is an AI-generated summary of the published abstract, not a clinical recommendation. It may not reflect the full text or subsequent updates — verify against the original source before acting on it.
Abstract
Background
Polycystic ovary syndrome (PCOS) is a common endocrine disorder affecting reproductive-aged women, with a global prevalence of 5%-10%, and up to 25% in certain populations. Developing countries like India have witnessed a surge in obesity and related metabolic comorbidities due to rapid urbanisation and lifestyle transitions. This study examines temporal changes in the clinical and metabolic profile of women with PCOS from Odisha, India, over the past 15 years.
Aim
This study aims to analyse how PCOS women have changed in their clinical, phenotypic, biochemical and metabolic parameters over the last two decades.
Settings and design
Private hospital and retrospective analysis.
Materials and methods
This retrospective chart review included 1530 women diagnosed with PCOS (Rotterdam criteria) at a tertiary care centre in Odisha. Patients were grouped into three periods: Period 1 (2009-2013), Period 2 (2014-2018) and Period 3 (2019-2024), with approximately equal numbers. Anthropometric, biochemical and ultrasonographic features were compared across time periods.
Statistical analysis used
The data were analysed using Chi-square and Kruskal-Wallis tests and the R v4.1.1 (R Core Team, 2021) software.
Results
Mean body mass index increased from 26.40 ± 4.61 kg/m2 (Period 1) to 28.42 ± 5.31 kg/m2 (Period 3), P P P P < 0.001 also increased significantly. Family history of PCOS, diabetes mellitus, hypertension, obesity and dyslipidaemias significantly increased, indicating a rising prevalence of these conditions over time. Menstrual dysfunction remained consistently prevalent, with cycles of 60-90 days most frequent in Period 2 (59.1%). Metabolic syndrome prevalence increased from 36.5% to 45.6.
Conclusion
Over the last 15 years, the metabolic and phenotypic profile of Indian women with PCOS has worsened significantly. These findings highlight the need for early lifestyle interventions and public health strategies targeting metabolic risk factors in this population.
DOI
10.4103/jhrs.jhrs_143_25
PMID
41560880
PMCID
PMC12815417
Research metadata (titles, abstracts, authors, publication dates) is sourced from Europe PMC, which aggregates content from PubMed/MEDLINE, PubMed Central, and other providers under the U.S. National Library of Medicine (NLM/NCBI). NLM does not claim copyright on abstracts; the original journal publishers or authors may hold rights to the full articles. AI-generated summaries are derived only from the abstract, never the full text, and are always labeled as AI-generated.
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