Journal of neurointerventional surgery
September 18, 2026 · via Europe PMC
Anxiety and mood disorders are associated with greater healthcare and procedural utilization in idiopathic intracranial hypertension.
Alsalama A, Essibayi MA, Dhaduk V, +13 more, Lakhani DA.
AI summary — for doctors, generated from the abstract only
IIH patients with anxiety or mood disorders had higher 5-year rates of CSF shunting, venous sinus stenting, admissions and ED visits, but lower mortality.
What was studied
Propensity-matched retrospective cohort study using TriNetX US network data, comparing 38,117 IIH patients with and without anxiety/mood disorders diagnosed since 2016.
Key findings
- CSF shunting 5.86% vs 4.62% (HR 1.17)
- Venous sinus stenting 1.40% vs 1.09% (HR 1.24)
- ED visits 56.6% vs 42.6% (HR 1.52); admissions 45.6% vs 36.9%
- Mortality 7.70% vs 9.67% (HR 0.73)
Clinical relevance
This suggests anxiety and mood disorders are linked to greater IIH care utilization, which may inform multidisciplinary care, though causality cannot be inferred.
Who should care
Limitations
Observational claims-type EHR data subject to coding inaccuracies and residual confounding.
IIH patients with anxiety or depression use more procedures and healthcare.
This is an AI-generated summary of the published abstract, not a clinical recommendation. It may not reflect the full text or subsequent updates — verify against the original source before acting on it.
Abstract
Background and purpose
Anxiety and mood disorders (AMD) are common in idiopathic intracranial hypertension (IIH), but their association with procedural treatment and healthcare utilization is unclear. We evaluated utilization among patients with AMD documented before or shortly after IIH.
Methods
Using the TriNetX US Collaborative Network, we identified adults diagnosed with IIH on or after January 1, 2016. The primary analysis compared patients with AMD documented on or before IIH with those without AMD; the sensitivity analysis compared patients with a first AMD diagnosis within 1 month after IIH with those without AMD before or during that month. Each analysis used separate 1:1 propensity-score matching. 5-year outcomes were assessed using Kaplan-Meier methods and Cox regression.
Results
The primary analysis included 38 117 matched patients per group. At 5 years, patients with AMD had higher rates of cerebrospinal fluid shunting (5.86% vs 4.62%; HR 1.168), transverse venous sinus stenting (1.40% vs 1.09%; HR 1.236), either procedure (7.12% vs 5.61%; HR 1.178), inpatient admission (45.63% vs 36.88%; HR 1.214), and emergency department visits (56.57% vs 42.57%; HR 1.519), but lower mortality (7.70% vs 9.67%; HR 0.725). The sensitivity analysis included 8949 matched patients per group and showed the same pattern among patients with AMD newly diagnosed within 1 month after IIH.
Conclusions
AMD documented before or shortly after IIH was associated with greater procedural and healthcare utilization. These observational findings describe patterns of care but do not establish that AMD causes greater IIH severity or procedural need.
DOI
10.1136/jnis-2026-026039
PMID
42760132
Research metadata (titles, abstracts, authors, publication dates) is sourced from Europe PMC, which aggregates content from PubMed/MEDLINE, PubMed Central, and other providers under the U.S. National Library of Medicine (NLM/NCBI). NLM does not claim copyright on abstracts; the original journal publishers or authors may hold rights to the full articles. AI-generated summaries are derived only from the abstract, never the full text, and are always labeled as AI-generated.
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