Journal of neurointerventional surgery
September 11, 2026 · via Europe PMC
Super large bore catheters in the treatment of stroke: systematic review.
Jabłońska M, Ribo M.
AI summary — for doctors, generated from the abstract only
Super large bore aspiration catheters reached the occlusion in 92% and achieved about 55% first-pass effect and 81% mTICI 2c-3 in pooled studies.
What was studied
Systematic review of 9 studies (532 patients) using aspiration catheters with inner diameter of at least 0.080 inch as first-line thrombectomy for LVO.
Key findings
- Thrombus access 92.1%
- First-pass effect 55%
- Final mTICI 2c-3 81%
- 90-day mRS 0-2 47.9%; median puncture-to-recanalization 22 min
Clinical relevance
This suggests super large bore catheters are navigable and safe, but first-pass rates are not clearly superior and randomized data are lacking.
Who should care
Limitations
Non-randomized, single-arm, heterogeneous studies.
Super large bore catheters are promising but not yet proven better.
This is an AI-generated summary of the published abstract, not a clinical recommendation. It may not reflect the full text or subsequent updates — verify against the original source before acting on it.
Abstract
Background
Super large bore aspiration catheters (SLACs; inner diameter ≥0.080 inch) have been introduced to enhance efficacy in mechanical thrombectomy for large vessel occlusion (LVO). Although their use is expanding, clinical data are fragmented across heterogeneous studies. This systematic review aimed to synthesize current evidence on the procedural efficacy and safety of SLACs.
Methods
A systematic search of PubMed (January 2018-September 2025) was performed in accordance with PRISMA guidelines. Studies were eligible if they included ≥20 patients with LVO treated using an aspiration catheter with an inner diameter ≥0.080 inch as the first line device. Recorded outcomes included first pass effect (FPE), modified Thrombolysis in Cerebral Infarction (mTICI) ≥2c/3, final reperfusion (mTICI ≥2b-3 and mTICI ≥2c-3), symptomatic intracranial hemorrhage, procedural time, and device related complications. Pooled weighted proportions and weighted medians with ranges were calculated.
Results
Nine studies met the inclusion criteria, encompassing 532 patients treated with six SLAC models. The pooled thrombus access rate was 92.1% (range 82-100%). Mean FPE was 55% (39-73%), and the final successful reperfusion rate (mTICI ≥2c-3) reached 81% (63-94%), including rescue strategies. The median puncture-to-recanalization time was 22 min (IQR 15-37). Among studies reporting functional outcomes (n=6), a favorable outcome (mRS score of 0-2) was achieved in 42% at discharge and in 47.9% at 90 days.
Conclusions
While SLACs seemed to consistently navigate up to the intracranial occlusion level with low complication rates, the rate of FPE was approximately 55%. Early results are promising, but most data derive from non-randomized or single arm studies. Larger prospective trials are required to define the optimal role of SLACs within contemporary endovascular stroke treatment.
DOI
10.1136/jnis-2026-025001
PMID
41895845
Research metadata (titles, abstracts, authors, publication dates) is sourced from Europe PMC, which aggregates content from PubMed/MEDLINE, PubMed Central, and other providers under the U.S. National Library of Medicine (NLM/NCBI). NLM does not claim copyright on abstracts; the original journal publishers or authors may hold rights to the full articles. AI-generated summaries are derived only from the abstract, never the full text, and are always labeled as AI-generated.
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