Emerging infectious diseases
October 1, 2026 · via Europe PMC
Emergence of Macrolide-Resistant Bordetella pertussis, Peru, 2025.
Juscamayta-López E, Valdivia F, Rodríguez-Cueva C, +9 more, Da Costa AR
AI summary — for doctors, generated from the abstract only
Macrolide-resistant B. pertussis with the A2047G mutation was found in 31% of 68 cases in a Peruvian outbreak.
What was studied
Outbreak genomic investigation including whole-genome sequencing.
Key findings
- 31% of 68 cases carried A2047G
- WGS showed two genetically distinct groups
- Findings suggest multiple introductions into Peru
Clinical relevance
Macrolide resistance could compromise first-line pertussis treatment and prophylaxis.
Who should care
Limitations
Small number of cases, one country.
Consider macrolide-resistant pertussis in treatment failure and obtain susceptibility testing where possible.
This is an AI-generated summary of the published abstract, not a clinical recommendation. It may not reflect the full text or subsequent updates — verify against the original source before acting on it.
Abstract
We report the emergence of macrolide-resistant Bordetella pertussis during a pertussis outbreak in Peru. Among 68 cases, 31% carried the A2047G gene mutation, conferring resistance to macrolides. Whole-genome sequencing revealed 2 genetically distinct groups, indicating multiple introductions into Peru. Our findings support strengthening surveillance for macrolide-resistant pertussis to inform control strategies.
DOI
10.3201/eid3210.251477
PMID
42811428
Research metadata (titles, abstracts, authors, publication dates) is sourced from Europe PMC, which aggregates content from PubMed/MEDLINE, PubMed Central, and other providers under the U.S. National Library of Medicine (NLM/NCBI). NLM does not claim copyright on abstracts; the original journal publishers or authors may hold rights to the full articles. AI-generated summaries are derived only from the abstract, never the full text, and are always labeled as AI-generated.
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