HPB : the official journal of the International Hepato Pancreato Biliary Association
September 19, 2026 · via Europe PMC
Infectious complications after liver resection in patients with prior biliary-enteric anastomosis: a multicenter retrospective cohort study.
Sano H, Urade T, Takebe A, +13 more, Fukumoto T.
AI summary — for doctors, generated from the abstract only
Liver resection after biliary-enteric anastomosis carries a high risk of organ/space infection, with concave transection surface a possible risk factor.
What was studied
Multicenter retrospective study of 26 Japanese patients with prior biliary-enteric anastomosis undergoing hepatectomy.
Key findings
- Organ/space SSI occurred in 10 patients and any infection in 13
- All cultured isolates were enteric organisms
- Concave transection surface had more SSI (8 of 13 vs 2 of 13; P=0.041) and infection prolonged stay (28.5 vs 13 days)
Clinical relevance
Alerts surgeons that this population is high risk and may benefit from technique and prophylaxis planning.
Who should care
Limitations
Only 26 patients with univariable analysis, so findings are exploratory.
Anticipate infection risk and consider transection surface shape and perioperative strategy in such cases.
This is an AI-generated summary of the published abstract, not a clinical recommendation. It may not reflect the full text or subsequent updates — verify against the original source before acting on it.
Abstract
Background
Liver resection in patients with prior biliary-enteric anastomosis (BEA) is associated with high rates of infectious complications. We evaluated the incidence, patterns, and risk factors.
Methods
This multicenter retrospective study included patients with prior BEA who underwent liver resection at three Japanese institutions between 2008 and 2025. The primary endpoint was organ/space surgical site infection (SSI) within 30 days postoperatively. Univariable analyses were performed to identify factors associated with organ/space SSI, comparing patients with and without this complication.
Results
Among the 26 patients, pancreatoduodenectomy was the most common preceding BEA procedure. Organ/space SSI occurred in 10 patients, and overall infectious complications occurred in 13 patients, including 3 with other infections. Cultures were positive in 6 of 10 organ/space SSI cases, and all isolates were enteric organisms. Organ/space SSI occurred more frequently with concave-type than flat-type transection surface morphology (8 of 13 vs. 2 of 13; P = 0.041). Organ/space SSI was associated with significantly prolonged postoperative hospital stay (median [range], 28.5 [13-94] vs. 13 [6-105] days; P = 0.003).
Conclusion
Liver resection after BEA carries a substantial risk of postoperative organ/space SSI. Concave transection surface morphology may represent a clinically relevant risk factor in this high-risk population.
DOI
10.1016/j.hpb.2026.09.004
PMID
42827057
Research metadata (titles, abstracts, authors, publication dates) is sourced from Europe PMC, which aggregates content from PubMed/MEDLINE, PubMed Central, and other providers under the U.S. National Library of Medicine (NLM/NCBI). NLM does not claim copyright on abstracts; the original journal publishers or authors may hold rights to the full articles. AI-generated summaries are derived only from the abstract, never the full text, and are always labeled as AI-generated.
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