Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences
November 27, 2025 · via Europe PMC
Early experience with the SmartGUIDE: A new generation of in-situ deflectable 0.014-inch guidewire.
Al-Tibi M, Lord J, Islam S, +6 more, Mosimann PJ
AI summary — for doctors, generated from the abstract only
A new deflectable-tip guidewire (SmartGUIDE) achieved high technical success (96%) navigating challenging neurovascular targets across a range of procedures, with no device-related complications in this early experience.
What was studied
Retrospective analysis of 25 neurointerventional procedures (May 2024-July 2025) using the SmartGUIDE deflectable-tip 0.014-inch guidewire, assessing technical success and periprocedural complications across aneurysm embolization, AVM/fistula embolization, tumor embolization, stenting, balloon test occlusion, and thrombectomy.
Key findings
- SmartGUIDE successfully reached the target vessel independently in 24 of 25 cases (96%) without needing an adjunctive device or alternative microwire.
- No device-related complications (perforation, dissection) occurred.
- All patients were discharged at baseline clinical status, except the thrombectomy patient who improved by 7 NIHSS points.
- The deflectable locking tip helped prevent microcatheters from herniating into the parent vessel during side-branch navigation.
Clinical relevance
Introduces a new tool that may simplify microcatheter navigation to difficult-to-reach neurovascular targets without requiring repeated manual tip-shaping or adjunct devices.
Who should care
Limitations
Small, single early-experience case series (25 procedures), no comparison group against standard guidewires, authors call for larger studies to confirm effectiveness across broader indications.
A new deflectable guidewire successfully reached difficult brain-vessel targets in 96% of early cases without complications.
This is an AI-generated summary of the published abstract, not a clinical recommendation. It may not reflect the full text or subsequent updates — verify against the original source before acting on it.
Abstract
BackgroundNeurointerventional procedures are increasingly complex, requiring access to more distal vasculature. SmartGUIDE 0.014-inch guidewire (Artiria Medical, Geneva, Switzerland) is an FDA-approved dynamic deflectable-tip guidewire, manipulated by an external handle to lock the distal end, allowing active shaping of micro/balloon catheters. We report the first clinical experience using the SmartGUIDE in various neurovascular interventions.MethodsNeurointerventional procedures utilizing the SmartGUIDE from May 2024 to July 2025 were retrospectively analyzed. Clinical outcomes, technical success, and periprocedural complications were assessed. The primary endpoint was successful delivery of a microcatheter tip using the SmartGUIDE to the predefined target without the use of an adjunctive device or microwire. Procedures requiring alternative microwires to replace SmartGUIDE were considered unsuccessful.ResultsThe SmartGUIDE was used in 25 procedures: aneurysm embolization (9), arteriovenous malformation/fistula embolization (5), tumor embolization (4), venous and carotid stenting (4), balloon test occlusion (2) and endovascular thrombectomy (1). SmartGUIDE enabled access to challenging neurovascular targets, successfully reaching the target vessel independently in 24/25; 96% of cases. No device-related complications incurred, such as perforation or dissection. All patients were discharged at their baseline clinical status, except the EVT patient who improved by seven NIHSS points.ConclusionsSmartGUIDE's deflectable-tip wire achieved high technical success and proved safe across various neurointervention. SmartGUIDE improves microcatheter navigation without repeated ex-vivo tip shaping, adjunct tools, or looping through aneurysms. Locking the SmartGUIDE tip can deflect microcatheters and prevent them from herniating into their parent vessel during side branch navigation. Larger studies are needed to evaluate effectiveness across broader clinical indications.
DOI
10.1177/15910199251399461
PMID
41308048
PMCID
PMC12660130
Research metadata (titles, abstracts, authors, publication dates) is sourced from Europe PMC, which aggregates content from PubMed/MEDLINE, PubMed Central, and other providers under the U.S. National Library of Medicine (NLM/NCBI). NLM does not claim copyright on abstracts; the original journal publishers or authors may hold rights to the full articles. AI-generated summaries are derived only from the abstract, never the full text, and are always labeled as AI-generated.
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