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British journal of neurosurgery

June 27, 2026 ยท via Europe PMC

Does early surgical intervention for type II dens fractures improve survival in octogenarians? A propensity-matched analysis.

Khan Z, Kim KT, Patel P, Chryssikos T

Journal ArticleAbstract only โ€” full text under license

AI summary โ€” for doctors, generated from the abstract only

In octogenarians with type II dens fractures, early surgery did not improve survival but reduced readmission and long-term opioid use.

What was studied

TriNetX propensity-matched retrospective cohort of 156 patients per group, surgery within 14 days vs nonoperative.

Key findings

  • No mortality difference at 9 months to 3 years.
  • Readmission was lower at 90 days (7.1% vs 17.9%) and 6 months (9.0% vs 21.2%).
  • Long-term opioid use was lower (16.0% vs 26.9%).

Clinical relevance

Guides decisions in frail older patients.

Who should care

Neurosurgery

Limitations

Retrospective database with possible residual confounding.

Discuss surgery as lowering readmission and opioid use, not survival.

This is an AI-generated summary of the published abstract, not a clinical recommendation. It may not reflect the full text or subsequent updates โ€” verify against the original source before acting on it.

Abstract

STUDY DESIGN

Retrospective Cohort Study.

OBJECTIVES

To compare mortality and downstream morbidity after early operative versus nonoperative management of isolated Type II dens fractures in octogenarians.

METHODS

TriNetX was queried to identify patients aged 80 years and older with a new diagnosis of Type II dens fracture. Patients with spinal cord injury, traumatic brain injury, or other major traumatic injuries were excluded. Patients were stratified by early operative intervention, defined as surgical fixation within 14 days, versus nonoperative management, defined as no surgical fixation after diagnosis. The primary outcome was mortality. Propensity score matching was performed 1:1 using demographic and clinical variables. Mortality was assessed at 9 months, 1 year, 2 years, and 3 years. Secondary outcomes included hospital readmission and long-term post-injury opioid use between 6 months and 3 years.

RESULTS

After matching, 156 patients were included in each cohort. No significant differences in mortality were observed between cohorts at 9 months, 1 year, 2 years, or 3 years. Early operative intervention was associated with lower 90-day readmission (7.1% vs 17.9%; OR 0.35, 95% CI 0.17-0.73;โ€‰=โ€‰0.0036), lower 6-month readmission (9.0% vs 21.2%; OR 0.37, 95% CI 0.19-0.72;โ€‰=โ€‰0.0026), and lower long-term post-injury opioid use (16.0% vs 26.9%; OR 0.52, 95% CI 0.30-0.90;โ€‰=โ€‰0.0191).

CONCLUSIONS

In octogenarians with isolated Type II dens fractures, early surgery was not associated with improved long-term mortality, but was associated with lower readmission and reduced long-term post-injury opioid use.

DOI

10.1080/02688697.2026.2695383

PMID

42364088

Research metadata (titles, abstracts, authors, publication dates) is sourced from Europe PMC, which aggregates content from PubMed/MEDLINE, PubMed Central, and other providers under the U.S. National Library of Medicine (NLM/NCBI). NLM does not claim copyright on abstracts; the original journal publishers or authors may hold rights to the full articles. AI-generated summaries are derived only from the abstract, never the full text, and are always labeled as AI-generated.

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