Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
October 12, 2026 · via Europe PMC
Surgical management of gastric gastrointestinal stromal tumours (GISTs): a tertiary centre experience over 16 years.
Anderson DJ, Douglass B, Williams B, +6 more, Forshaw MJ
AI summary — for doctors, generated from the abstract only
Surgery for gastric GIST had high R0 rates and low morbidity, with recurrence and death concentrated in high-risk tumors.
What was studied
Single tertiary-center review of 85 patients resected for gastric GIST (2009-2025) from a prospective database, with AFIP risk stratification and comparison of laparoscopic and open wedge resection.
Key findings
- R0 resection was 94.1%, with no in-hospital deaths and 27.1% morbidity.
- Five-year disease-specific survival was 98.5% and recurrence-free survival 95.9%.
- Laparoscopic resection use rose to 48% and showed no oncological penalty in matched tumours.
Clinical relevance
Surgeons and oncologists can use these data to support laparoscopic wedge resection and risk-stratified adjuvant imatinib.
Who should care
Limitations
Single-center, non-randomized and relatively small, so the laparoscopic comparison may be affected by case selection.
Resect gastric GIST laparoscopically when suitable and focus adjuvant therapy on high-risk disease.
This is an AI-generated summary of the published abstract, not a clinical recommendation. It may not reflect the full text or subsequent updates — verify against the original source before acting on it.
Abstract
BACKGROUND
Complete surgical resection is the mainstay of curative treatment for gastric gastrointestinal stromal tumours (GISTs). This study characterised outcomes of surgical management at a tertiary oesophagogastric centre, comparing operative approaches and examining factors influencing recurrence and disease-related mortality.
METHODS
Patients undergoing resection for gastric GIST between June 2009 and May 2025 were identified from a prospectively maintained database. Risk was stratified by Miettinen and Lasota (AFIP) criteria. Survival was estimated by Kaplan-Meier and compared by log-rank test; laparoscopic and open wedge resections were compared directly.
RESULTS
Eighty-five patients were included. Laparoscopic resection rose from 11.4% (2009-2016) to 48.0% (2017-2025; p=0.001). R0 resection was 94.1%, with no in-hospital mortality and 27.1% morbidity. Over a median 7.2 years, six patients (7.1%) recurred and two (2.4%) died of GIST. Five-year DSS and RFS were 98.5% and 95.9%. Outcomes were risk-stratified: 10-year DSS was 83.3% in high-risk versus 100% in lower-risk disease (p=0.010), and 10-year RFS 69.7% versus 100% (p<0.001). Laparoscopic and open wedge resections were size- and risk-matched, with no excess morbidity, rupture, involved margins, or recurrence after laparoscopy, which extended to tumours of 120mm. Recurrence was associated with tumour size (142 versus 51mm; p=0.018) and rupture (25.0% versus 2.9%; p=0.010).
CONCLUSION
Gastric GIST is managed surgically with low morbidity, no perioperative mortality, and high R0 rates. Recurrence and disease-specific mortality concentrate in high-risk, larger, and ruptured tumours, supporting risk stratification and adjuvant imatinib. Laparoscopic wedge resection carried no oncological penalty in matched tumours.
DOI
10.1016/j.gassur.2026.102628
PMID
42863699
Research metadata (titles, abstracts, authors, publication dates) is sourced from Europe PMC, which aggregates content from PubMed/MEDLINE, PubMed Central, and other providers under the U.S. National Library of Medicine (NLM/NCBI). NLM does not claim copyright on abstracts; the original journal publishers or authors may hold rights to the full articles. AI-generated summaries are derived only from the abstract, never the full text, and are always labeled as AI-generated.
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