Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
October 9, 2026 · via Europe PMC
Characteristics of metagenome and metabolomics of biliary flora in biliary acute pancreatitis for severity prediction.
Zhang Y, Lu R
AI summary — for doctors, generated from the abstract only
Biliary flora and inflammatory markers tracked severity of acute biliary pancreatitis.
What was studied
Study of 80 patients with acute biliary pancreatitis (50 mild, 30 moderate-severe) and 30 healthy controls, comparing biliary microbial diversity, Klebsiella, Enterococcus and E. coli abundance, amylase and CRP, with ROC analysis.
Key findings
- Groups differed in diversity indices, genera abundance, amylase and CRP
- Shannon index, Klebsiella abundance and CRP were tested for severity prediction
- Biliary microbiome features were associated with severity
Clinical relevance
Gastroenterologists and surgeons may eventually use bile microbiome features for early severity stratification.
Who should care
Limitations
Small single-cohort study with no external validation, and bile sampling is invasive.
Interesting but exploratory; rely on established severity criteria.
This is an AI-generated summary of the published abstract, not a clinical recommendation. It may not reflect the full text or subsequent updates — verify against the original source before acting on it.
Abstract
OBJECTIVE
To investigate the characteristics of the metagenome and metabolomics of biliary flora in patients with acute biliary pancreatitis and its predictive value for the severity of the disease.
METHODS
This study included 80 ABP patients (Jan 2022 - Dec 2024) and 30 healthy controls. ABP patients were divided into mild (n = 50) and moderate-severe (n = 30) groups using the revised Atlanta criteria. Chao1 index, Shannon index, relative abundances of Klebsiella, Enterococcus, and Escherichia coli, serum amylase, and C-reactive protein (CRP) were compared. ROC analysis assessed predictive value of Shannon index, Klebsiella abundance, and CRP for severity. Correlations between these parameters and severity were examined.
RESULTS
Significant differences were observed among the three groups in Chao1 and Shannon indices, relative abundances of the three bacterial genera, and serum amylase and CRP levels (all P < 0.05). ROC analysis showed that Shannon index, Klebsiella relative abundance, and CRP level predicted disease severity with AUCs of 0.804, 0.804, and 0.850, respectively (P < 0.05). Shannon index was negatively correlated with ABP severity, while Klebsiella abundance and CRP level were positively correlated with severity (P < 0.05).
CONCLUSION
In this cohort, biliary microbiome characteristics and serum inflammatory markers were associated with the severity of biliary acute pancreatitis. The Shannon index, Klebsiella relative abundance, and CRP showed exploratory discriminatory performance. These findings provide a basis for further prospective validation; they do not establish a causal driving factor, a clinically validated early-warning system, or an individualized treatment strategy.
DOI
10.1016/j.gassur.2026.102625
PMID
42854825
Research metadata (titles, abstracts, authors, publication dates) is sourced from Europe PMC, which aggregates content from PubMed/MEDLINE, PubMed Central, and other providers under the U.S. National Library of Medicine (NLM/NCBI). NLM does not claim copyright on abstracts; the original journal publishers or authors may hold rights to the full articles. AI-generated summaries are derived only from the abstract, never the full text, and are always labeled as AI-generated.
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