Histopathology
June 28, 2026 · via Europe PMC
Malignant adenomyoepithelioma of the breast: seven cases illustrating morphological diversity and diagnostic challenges.
Apornvirat S, Hadi EJ, Gudi M, +12 more, Tan PH.
AI summary — for doctors, generated from the abstract only
Seven cases show malignant adenomyoepithelioma of the breast is morphologically diverse and overlaps with classic AME and metaplastic carcinoma, requiring combined morphologic, immunohistochemical and molecular assessment.
What was studied
Retrospective clinicopathological review of seven M-AME cases in women aged 45-74 (median 53), each with different architectural patterns.
Key findings
- Seven cases from women aged 45-74 years, median 53
- Patterns included in situ and invasive M-AME, and one atypical AME with late lung metastasis carrying HRAS p.G13R and a PIK3R1 in-frame deletion
- Authors propose classification as in situ or invasive M-AME or conventional carcinoma arising in AME
Clinical relevance
Helps pathologists recognise underlying AME architecture and avoid misclassification, which guides management.
Who should care
Limitations
Very small case series from a rare entity; no outcome or follow-up data in the abstract.
Look for the AME architecture and correlate with IHC and molecular findings when classifying.
This is an AI-generated summary of the published abstract, not a clinical recommendation. It may not reflect the full text or subsequent updates — verify against the original source before acting on it.
Abstract
Background
Malignant adenomyoepithelioma (M-AME) is an extremely rare and morphologically diverse breast tumour, posing significant diagnostic and management challenges. We present seven cases of M-AME with different histological compositions to contribute additional data to the existing literature. Through these cases, we review and discuss potential pitfalls and classification challenges in diagnosing M-AME.
Methods and results
We performed a retrospective clinicopathological review of seven cases of M-AME from women aged 45-74 years (median 53 years). Each case exhibited distinct architectural patterns and compositions of classic and malignant components: (1) Adenomyoepithelioma (AME) with metaplastic spindle and squamous cell carcinoma; (2) Invasive AME with an aberrant immunohistochemical profile; (3) Invasive AME with an adenomyoepithelial adenosis pattern; (4) Metaplastic spindle cell carcinoma arising from AME with suspicion of M-AME in situ; (5) Atypical AME with late lung metastasis harbouring HRAS p.G13R and in-frame PIK3R1 deletion; (6) and (7) M-AME in situ.
Conclusion
M-AME encompasses heterogeneous patterns that overlap with the infiltrative-like pattern of classic AME (adenomyoepithelial adenosis form of tubular AME) and metaplastic breast carcinoma. Recognition of the underlying AME architecture, coupled with immunohistochemical and molecular correlation, supports pragmatic classification into in situ or invasive M-AME or conventional breast carcinoma arising in the context of AME. Together with clinical, radiological, and molecular correlations, this approach can help guide appropriate management.
DOI
10.1111/his.70233
PMID
42365981
Research metadata (titles, abstracts, authors, publication dates) is sourced from Europe PMC, which aggregates content from PubMed/MEDLINE, PubMed Central, and other providers under the U.S. National Library of Medicine (NLM/NCBI). NLM does not claim copyright on abstracts; the original journal publishers or authors may hold rights to the full articles. AI-generated summaries are derived only from the abstract, never the full text, and are always labeled as AI-generated.
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