Journal of glaucoma
October 7, 2026 · via Europe PMC
Comparison of Early Outcomes of PreserFlo MicroShunt, Ex-PRESS, and Trabeculectomy in Primary Open-angle Glaucoma.
Otsuka M, Nitta Y, Akai R, Tojo N, Hayashi A.
AI summary — for doctors, generated from the abstract only
In early follow-up, PreserFlo MicroShunt achieved IOP control comparable to Ex-PRESS and trabeculectomy with fewer postoperative interventions.
What was studied
Retrospective single-center comparison of 394 eyes with primary open-angle glaucoma (78 PreserFlo, 193 Ex-PRESS, 123 trabeculectomy) with at least 6 months follow-up, using propensity-based overlap weighting.
Key findings
- Mean IOP at 6 months was modestly lower after trabeculectomy than PreserFlo, with no significant difference between PreserFlo and Ex-PRESS
- Qualified and complete success rates were comparable across procedures at all IOP thresholds
- PreserFlo had fewer postoperative interventions, without more major complications and with similar visual acuity
Clinical relevance
Supports PreserFlo as a reasonable option with lower postoperative maintenance burden.
Who should care
Limitations
Retrospective, single center, short follow-up (6 months); unmeasured confounding despite weighting; the abstract gives no numeric IOP values.
Short-term efficacy looks similar across the three procedures, with longer prospective data still needed.
This is an AI-generated summary of the published abstract, not a clinical recommendation. It may not reflect the full text or subsequent updates — verify against the original source before acting on it.
Abstract
Precis
In primary open-angle glaucoma, PreserFlo MicroShunt achieved early intraocular pressure reduction comparable to Ex-PRESS and trabeculectomy, with fewer postoperative interventions.
Purpose
To compare short-term outcomes of PreserFlo MicroShunt (PFM), Ex-PRESS (EXP), and trabeculectomy (TLE) in primary open-angle glaucoma.
Methods
In this retrospective single-center study, 394 eyes undergoing PFM (78 eyes), EXP (193 eyes), or TLE (123 eyes) with ≥6 months follow-up were analyzed. Pairwise comparisons were performed using propensity score-based overlap weighting with doubly robust models. Surgical success was defined as ≥20% intraocular pressure (IOP) reduction with absolute IOP thresholds (≤21, ≤18, ≤15, ≤12 mmHg) without additional glaucoma surgery, laser treatment, or surgery for complications. Needling, laser suture lysis, and conjunctival resuturing were analyzed as postoperative interventions.
Results
At 6 months, mean IOP was modestly lower after TLE compared with PFM, whereas no significant difference was observed between PFM and EXP. Qualified and complete success rates were comparable across procedures at all IOP thresholds. PFM was associated with fewer postoperative interventions than both EXP and TLE. Major complications were not increased with PFM, and visual acuity outcomes were similar among groups after adjustment.
Conclusions
PFM demonstrated short-term outcomes broadly comparable to EXP and TLE, with a lower postoperative intervention burden. Longer-term prospective studies are needed.
DOI
10.1097/ijg.0000000000002792
PMID
42842868
Research metadata (titles, abstracts, authors, publication dates) is sourced from Europe PMC, which aggregates content from PubMed/MEDLINE, PubMed Central, and other providers under the U.S. National Library of Medicine (NLM/NCBI). NLM does not claim copyright on abstracts; the original journal publishers or authors may hold rights to the full articles. AI-generated summaries are derived only from the abstract, never the full text, and are always labeled as AI-generated.
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