Acta neurochirurgica
October 16, 2026 · via Europe PMC
Targeting health-related quality of life issues not found with functional outcome measures a year after aneurysm subarachnoid hemorrhage in a Swedish national cohort.
Aineskog H, Baldvinsdóttir B, Nilsson OG, +7 more, Lindvall P
AI summary — for doctors, generated from the abstract only
Aneurysmal SAH survivors with favorable functional outcome still reported more problems with usual activities and anxiety/depression than matched peers.
What was studied
Analysis of 634 Swedish aSAH patients, 471 with favorable GOSE, comparing EQ-5D-3L at one year with an age- and sex-matched population.
Key findings
- Mobility problems were less frequent (9.6% vs 14.7%; OR 0.62, p = 0.002)
- Moderate usual-activity difficulties were more common (24.0% vs 10.9%; OR 2.58)
- More extreme anxiety/depression issues were reported
Clinical relevance
Suggests follow-up should address activities and mood even when function looks good.
Who should care
Limitations
The abstract is truncated in the results; the comparison population is from 2006 in Stockholm only; observational.
Good functional scores can hide meaningful quality-of-life problems.
This is an AI-generated summary of the published abstract, not a clinical recommendation. It may not reflect the full text or subsequent updates — verify against the original source before acting on it.
Abstract
PURPOSE
Outcome after aneurysmal subarachnoid hemorrhage (aSAH) is often devastating with life time issues also for independent survivors. We aimed to identify health related quality of life (HRQoL) issues in this favorable functional outcome group compared to a sex and age matched general population.
METHODS
We have analyzed data from 634 Swedish aSAH patients from a national prospective study ranging between 2014 and 2018. One year after ictus, functional outcome was analyzed using Glasgow Outcome Scale Extended (GOSE) and HRQoL assessed by Euro-quality of life-5 dimensions-3 levels (EQ-5D-3L). Favorable GOSE (5-8) were found in 471 patients. Age- and sex-matched populations were created by published data from a cross-sectional cohort of 32,597 people living in Stockholm County in 2006. Odds ratios (ORs) for rating a specific EQ-5D-3L level were calculated for each domain. Significance was set at α = 0.001.
RESULTS
Patients reported less mobility problems than the matched general population (9.6% vs 14.7%; OR 0.62 p = 0.002). However, with usual activities significantly more difficulties with moderate, (24.0% vs 10.9%; OR 2.58, p < .001) and any problems (27.0% vs 12.5%; OR 2.58, p < .001) were reported. More issues with extreme anxiety/depression were also reported ((5.3% vs 2.8%; OR 1.94; p = 0.002). Unfavorable GOSE patients were doing worse than the matched population in all levels and dimensions measured (Online Resource 1, 2, 3 and 4).
CONCLUSION
Although patients with favorable functional outcome report good or better mobility compared to their age and sex matched general population, they have significantly more issues with usual activities a year after aSAH more extreme issues with anxiety/depression were also reported To our knowledge, this is the first time EQ-5D-3L data is compared in a national group of aSAH patients with favorable functional outcome to a sex and age matched general population.
DOI
10.1007/s00701-026-07059-z
PMID
42891758
Research metadata (titles, abstracts, authors, publication dates) is sourced from Europe PMC, which aggregates content from PubMed/MEDLINE, PubMed Central, and other providers under the U.S. National Library of Medicine (NLM/NCBI). NLM does not claim copyright on abstracts; the original journal publishers or authors may hold rights to the full articles. AI-generated summaries are derived only from the abstract, never the full text, and are always labeled as AI-generated.
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