International journal of cardiology
September 14, 2026 · via Europe PMC
Cardiac disease in pregnancy in Eastern Indonesia: a prospective regional registry from a tertiary referral center.
Pintaningrum Y, Danianto A, Indrayana Y, Affarah WS, Putra AASMM, Javier RM, Kurniawan K.
AI summary — for doctors, generated from the abstract only
In a one-year registry in Nusa Tenggara Barat, Indonesia, 3.8% of pregnant women managed had cardiac disease, with high rates of heart failure, preterm birth and maternal death.
What was studied
Prospective descriptive single-hospital registry (September 2023 to August 2024) consecutively enrolling pregnant women with cardiac disease at a tertiary referral hospital, describing diagnoses, comorbidities and maternal-fetal outcomes.
Key findings
- Of 1023 pregnant women managed, 39 (3.8%) had cardiac disease; valvular heart disease was present in 18.0% and arrhythmias in 23.1%
- Hypertension was the most common comorbidity (30.8%) and heart failure developed in 25.6%
- Maternal in-hospital mortality was 10.3% and 17.9% of pregnancies ended in preterm birth
Clinical relevance
Highlights the need for cardio-obstetric services, early risk stratification and preconception counselling in resource-limited settings.
Who should care
Limitations
Only 39 cardiac patients at one referral centre over one year, descriptive analysis without a comparison group or risk-adjustment, and referral bias likely inflates severity.
Pregnancy with heart disease in this region carries a heavy maternal burden, supporting structured regional care pathways.
This is an AI-generated summary of the published abstract, not a clinical recommendation. It may not reflect the full text or subsequent updates — verify against the original source before acting on it.
Abstract
Background
Cardiac disease complicating pregnancy is a major contributor to maternal morbidity and mortality worldwide, particularly in low- and middle-income countries where access to specialized care remains limited. Data from Eastern Indonesia are scarce, limiting effective risk stratification and health system planning. This study aimed to establish a prospective regional registry describing the burden, clinical spectrum, and outcomes of cardiac disease in pregnancy in a tertiary referral center.
Methods
A prospective descriptive registry was conducted at Regional General Hospital (RSUD) Provinsi Nusa Tenggara Barat, Indonesia, from September 2023 to August 2024. All pregnant women diagnosed with cardiac disease during pregnancy were consecutively enrolled. Maternal demographic characteristics, obstetric history, cardiac diagnoses, comorbidities, and maternal-fetal outcomes were collected and analyzed descriptively.
Results
Among 1023 pregnant women managed during the study period, 39 (3.8%) were diagnosed with cardiac disease. Most patients were multigravida, with third pregnancies being the most common (30.8%). Valvular heart disease was present in 18.0% of cases, predominantly involving the mitral valve. Cardiac arrhythmias occurred in 23.1%, including atrial fibrillation and supraventricular tachycardia. Hypertension was the most frequent cardiovascular comorbidity (30.8%). Heart failure developed in 25.6% of patients. Maternal in-hospital mortality was 10.3%, while 17.9% of pregnancies resulted in preterm birth.
Conclusion
Cardiac disease in pregnancy in Eastern Indonesia is associated with a high burden of maternal and neonatal complications, including heart failure, preterm birth, and substantial maternal mortality. These findings highlight the urgent need for structured cardio-obstetric services, early risk stratification, and preconception counseling. Regional prospective registries play a crucial role in informing context-specific strategies to reduce preventable adverse outcomes in resource-limited settings.
DOI
10.1016/j.ijcard.2026.134782
PMID
42735847
Research metadata (titles, abstracts, authors, publication dates) is sourced from Europe PMC, which aggregates content from PubMed/MEDLINE, PubMed Central, and other providers under the U.S. National Library of Medicine (NLM/NCBI). NLM does not claim copyright on abstracts; the original journal publishers or authors may hold rights to the full articles. AI-generated summaries are derived only from the abstract, never the full text, and are always labeled as AI-generated.
Want more like this?
Browse more from the feed. A free account unlocks the full feed, saving and communities.
Back to the research feed