Gland surgery
August 31, 2026 · via Europe PMC
Impact of postoperative hyperamylasemia and post-pancreatectomy acute pancreatitis following pancreaticoduodenectomy in a single-center cohort.
Asavachaisuvikom A, Tangtawee P, Rungsakulkij N, Suragul W, Mingphruedhi S, Muangkaew P.
AI summary — for doctors, generated from the abstract only
Post-pancreatectomy acute pancreatitis was common after pancreaticoduodenectomy and was linked to worse short-term outcomes, particularly alongside clinically relevant pancreatic fistula.
What was studied
Retrospective single-center study of 244 consecutive adults undergoing pancreaticoduodenectomy (2012-2025), using 2022 ISGPS definitions to assess incidence, risk factors and short-term impact of postoperative hyperamylasemia (POH) and PPAP.
Key findings
- 25.4% developed POH and 31.1% developed PPAP.
- PPAP was associated with more CR-POPF, Clavien-Dindo grade 3 or higher complications, and longer hospital and ICU stays, with no difference in 90-day mortality.
- Soft pancreatic texture (OR 2.58) and CR-POPF (OR 11.13 univariate) were linked to PPAP; male sex had OR 2.49 in multivariate analysis.
Clinical relevance
PPAP may serve as a marker of surgical morbidity and flag patients likely to have prolonged recovery, and soft gland texture helps identify those at higher risk.
Who should care
Limitations
Retrospective single-center design; the abstract is cut off in the multivariate results, so the full adjusted estimates cannot be reported. PPAP and fistula are closely related, making causal direction unclear.
PPAP is frequent after pancreaticoduodenectomy and tracks with morbidity and longer stays.
This is an AI-generated summary of the published abstract, not a clinical recommendation. It may not reflect the full text or subsequent updates — verify against the original source before acting on it.
Abstract
Background
The clinical significance of postoperative hyperamylasemia (POH) and post-pancreatectomy acute pancreatitis (PPAP) following pancreaticoduodenectomy (PD) is understudied. Hence, we aimed to determine the incidence, risk factors, and short-term clinical impact of post-PD POH and PPAP.
Methods
A retrospective, single-center, observational study was conducted with consecutive adult patients who underwent surgery between January 2012 and September 2025. POH and PPAP were defined and graded using the 2022 International Study Group of Pancreatic Surgery (ISGPS) consensus criteria.
Results
Among the 244 participants, 25.4% developed POH and 31.1% developed PPAP. Those with PPAP demonstrated significantly higher rates of clinically relevant postoperative pancreatic fistula (CR-POPF), postoperative complications (Clavien-Dindo classification ≥3), and longer hospital and intensive care unit (ICU) stays compared to those without PPAP. There was no difference in the 90-day mortality rate. Perioperative factors were significantly associated with PPAP in the univariate analysis, including male sex [odds ratio (OR) =1.83; 95% confidence interval (CI): 1.05-3.17; P=0.03] and the presence of preoperative biliary drainage (OR =1.84; 95% CI: 1.01-3.35; P=0.047). Two intraoperative characteristics were identified as significant risk factors for PPAP: soft pancreatic texture (OR =2.58; 95% CI: 1.39-4.81; P=0.003) and a narrower pancreatic duct (OR =0.77; 95% CI: 0.66-0.99; P=0.002). CR-POPF was associated with an increased incidence of PPAP (OR =11.13; 95% CI: 5.61-22.07; P=0.001). In the multivariate analysis, male sex (OR =2.49; 95% CI: 1.13-5.51; P=0.02) and CR-POPF (OR =17.55; 95% CI: 7.13-43.19; P<0.001) were identified as risk factors for PPAP.
Conclusions
PPAP is associated with an increased risk of adverse outcomes. It has potential as an indicator of surgical morbidity and of prolonged hospital and ICU stays.
DOI
10.21037/gs-2026-0374
PMID
42866823
Research metadata (titles, abstracts, authors, publication dates) is sourced from Europe PMC, which aggregates content from PubMed/MEDLINE, PubMed Central, and other providers under the U.S. National Library of Medicine (NLM/NCBI). NLM does not claim copyright on abstracts; the original journal publishers or authors may hold rights to the full articles. AI-generated summaries are derived only from the abstract, never the full text, and are always labeled as AI-generated.
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