Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus
October 6, 2026 · via Europe PMC
Central retinal vein occlusion in an adolescent with Klinefelter syndrome.
Dandolo C, Ambler G, Li J.
AI summary — for doctors, generated from the abstract only
Central retinal vein occlusion can occur in an adolescent with Klinefelter syndrome, possibly through a hypofibrinolytic state.
What was studied
Case report of a pediatric patient with CRVO and Klinefelter syndrome with no other comorbidities.
Key findings
- Pediatric CRVO is very rare and usually linked to prothrombotic disorders
- Klinefelter syndrome is associated with hematological abnormalities
- Authors propose androgen deficiency-related hypofibrinolysis plus genetic factors may raise risk
Clinical relevance
Consider a thrombotic workup and underlying syndromes such as Klinefelter in young patients with unexplained retinal vein occlusion.
Who should care
Limitations
Single case with a hypothesized mechanism that cannot show causation.
Think of Klinefelter syndrome and coagulation abnormalities when evaluating CRVO in children and adolescents.
This is an AI-generated summary of the published abstract, not a clinical recommendation. It may not reflect the full text or subsequent updates — verify against the original source before acting on it.
Abstract
In children, central retinal vein occlusion (CRVO) is very rare and typically linked to underlying prothrombotic disorders. We describe a case of pediatric CRVO in the presence of Klinefelter syndrome (KS) with no other comorbidities. KS is associated with hematological abnormalities. This case suggests that a hypofibrinolytic state caused by androgen deficiency along with other genetic factors may contribute to CRVO risk.
DOI
10.1016/j.jaapos.2026.105314
PMID
42838336
Research metadata (titles, abstracts, authors, publication dates) is sourced from Europe PMC, which aggregates content from PubMed/MEDLINE, PubMed Central, and other providers under the U.S. National Library of Medicine (NLM/NCBI). NLM does not claim copyright on abstracts; the original journal publishers or authors may hold rights to the full articles. AI-generated summaries are derived only from the abstract, never the full text, and are always labeled as AI-generated.
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