Retina (Philadelphia, Pa.)
via Europe PMC
EVALUATING CLINICAL OUTCOMES OF AMNIOTIC MEMBRANE COVERAGE COMBINED WITH EARLY VITRECTOMY IN THE MANAGEMENT OF PERFORATING GLOBE INJURIES.
Xu H, Niu L, Jiang C, Jiang R.
AI summary — for doctors, generated from the abstract only
Amniotic membrane over the exit wound plus early low-pressure vitrectomy gave good anatomical results in zone 3 perforating globe injuries.
What was studied
Case series of 19 patients with zone 3 exit wounds treated with tPA, vitrectomy, ILM peeling or retinectomy, amniotic membrane coverage of the exit wound and tamponade, followed 6 months.
Key findings
- Retinal reattachment in 89.5% and 100% globe survival
- Postoperative PVR in 10.5%
- BCVA improved in 89.47%
Clinical relevance
May help manage complex posterior exit wounds in severe open-globe trauma.
Who should care
Limitations
Small uncontrolled series with only 6-month follow-up, so benefit of the amniotic membrane component is unproven.
Consider amniotic membrane coverage of posterior exit wounds in selected severe injuries, recognizing evidence is preliminary.
This is an AI-generated summary of the published abstract, not a clinical recommendation. It may not reflect the full text or subsequent updates — verify against the original source before acting on it.
Abstract
Purpose
To evaluate the anatomical and functional outcomes of a surgical approach combining amniotic membrane coverage with early vitrectomy under low perfusion pressure in patients with perforating globe injuries.
Methods
The study involved 19 patients who presented with Zone 3 exit wounds of globe injuries. The surgical procedures included the administration of recombinant tissue plasminogen activator for hemorrhage clearance, pars plana vitrectomy, internal limiting membrane peeling or retinectomy depending on the presence of proliferative vitreoretinopathy, application of amniotic membrane over the exit wound, and intraocular tamponade injection. The postoperative follow-up period extended over 6 months.
Results
Anatomical success, defined as retinal reattachment, was achieved in 89.5% of cases, with a 100% rate of globe survival. The incidence of postoperative proliferative vitreoretinopathy was 10.5%. Best-corrected visual acuity improved in 89.47% of patients.
Conclusion
The combination of amniotic membrane coverage with early vitrectomy in the management of perforating globe injuries was associated with favorable anatomical outcomes, a low rate of postoperative proliferative vitreoretinopathy, and visual improvement in most patients. This approach represents a viable strategy for addressing the complex challenges in these severe ocular injuries.
DOI
10.1097/iae.0000000000004726
PMID
42350910
Research metadata (titles, abstracts, authors, publication dates) is sourced from Europe PMC, which aggregates content from PubMed/MEDLINE, PubMed Central, and other providers under the U.S. National Library of Medicine (NLM/NCBI). NLM does not claim copyright on abstracts; the original journal publishers or authors may hold rights to the full articles. AI-generated summaries are derived only from the abstract, never the full text, and are always labeled as AI-generated.
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