Annals of surgical oncology
October 21, 2026 · via Europe PMC
Impact of the Prognostic Nutritional Index on Outcomes in Resectable Gallbladder Cancer.
Patkar S, Kale KD, Kazi M, Dhaiya A, Goel M
AI summary — for doctors, generated from the abstract only
A prognostic nutritional index of 48 or higher was associated with better survival after resection for gallbladder cancer.
What was studied
Retrospective cohort of 1,312 patients with radical resection for gallbladder cancer (2010-2024) at one cancer center, with PNI calculated from albumin and lymphocyte count at diagnosis.
Key findings
- Median OS was 28.6 months
- PNI was an independent predictor of OS in univariate and multivariate analyses
- Patients with PNI >=48 had survival advantages of 10% at 3 years and 13.2% at 5 years
Clinical relevance
PNI is a cheap lab-based marker of nutritional and inflammatory status that can help risk-stratify patients.
Who should care
Limitations
Retrospective single-center study with a data-derived cutoff and no evidence that improving PNI improves survival.
Check albumin and lymphocyte-based PNI at baseline and address nutrition, while recognizing causality is unproven.
This is an AI-generated summary of the published abstract, not a clinical recommendation. It may not reflect the full text or subsequent updates — verify against the original source before acting on it.
Abstract
BACKGROUND
Gallbladder cancer (GBC) is the most common malignancy of the biliary tract, with poor survival outcomes. This study was undertaken to assess whether the prognostic nutritional index (PNI) has any impact on survival outcomes for patients with resectable GBC.
METHODS
A retrospective study analyzed patients who underwent radical resection for GBC at a tertiary care cancer center from 1 January 2010 to 31 December 2024. The PNI was calculated with serum albumin and absolute lymphocyte count at the time of diagnosis (before neoadjuvant or operative treatment) and was correlated with survival.
RESULTS
The study enrolled 1312 patients, with a median follow-up period of 39.9 months. The median overall survival (OS) for the entire cohort was 28.6 months. The mean PNI for the entire cohort was 51.84. The PNI was an independent predictor of OS in both the uni- and multivariate analyses. The PNI cutoff estimated with maximally distributed rank statistics for OS was 48. The log-rank test showed that patients with PNI of 48 or higher had significantly better survival, with a differential OS in the two PNI cutoff groups of 10% at 3 years and 13.2% at 5 years.
CONCLUSION
In resectable GBC, PNI correlates with OS. This highlights systemic effects of cancer-host interaction on the inflammatory and nutritional status of patients, with an impact on long-term outcomes. Strategies aimed at improving nutritional and immunologic status in tandem with the standard-of-care cancer treatment may have an impact on survival.
DOI
10.1245/s10434-026-20703-3
PMID
42907710
Research metadata (titles, abstracts, authors, publication dates) is sourced from Europe PMC, which aggregates content from PubMed/MEDLINE, PubMed Central, and other providers under the U.S. National Library of Medicine (NLM/NCBI). NLM does not claim copyright on abstracts; the original journal publishers or authors may hold rights to the full articles. AI-generated summaries are derived only from the abstract, never the full text, and are always labeled as AI-generated.
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