Plastic and reconstructive surgery. Global open
October 20, 2026 · via Europe PMC
Serasynth Mesh BR Pocket in Prepectoral Direct-to-implant and Tissue-expander Breast Reconstruction: A Retrospective Single-center Analysis.
Wimmer F, Panzirsch A, Hitzl W, Djedovic G.
AI summary — for doctors, generated from the abstract only
A fully resorbable mesh pocket gave acceptable short-term results in prepectoral breast reconstruction, but complications were not trivial and risk was higher with high BMI and axillary node surgery.
What was studied
Retrospective single-center review of 53 breasts (43 patients) reconstructed with direct-to-implant or tissue expander after nipple- or skin-sparing mastectomy using Serasynth Mesh BR Pocket, with at least 4 weeks follow-up.
Key findings
- 83% of breasts needed no further surgery over a mean of 10 months.
- Major complications occurred in 17% and minor in 24.5%.
- Implant loss was 13.2%, mainly from necrosis (7.5%).
- BMI of 27 or more and axillary lymph node excision were linked to more complications; 41.9% received radiotherapy.
Clinical relevance
Surgeons choosing synthetic mesh for prepectoral reconstruction get reassurance that this resorbable product performs similarly to other meshes, along with a reminder to select patients carefully.
Who should care
Limitations
Retrospective, single-arm, small and short follow-up, with no comparison group to show it is equal to other meshes.
Consider this mesh in prepectoral reconstruction but counsel higher-BMI patients and those needing axillary dissection about greater complication risk.
This is an AI-generated summary of the published abstract, not a clinical recommendation. It may not reflect the full text or subsequent updates — verify against the original source before acting on it.
Abstract
Background
Prepectoral implant-based breast reconstruction after nipple-sparing mastectomy or skin-sparing mastectomy has already shown several advantages. Synthetic meshes are often used as a supportive layer to achieve satisfying and stable results. We present our data using Serasynth Mesh BR Pocket, a fully dissolvable, ready-to-use mesh pocket.
Methods
Between December 2021 and August 2023, a single-center retrospective study evaluated 53 breast reconstructions (43 patients) for short-term complications. Complications were classified as major (requiring revision surgery) or minor (managed conservatively). All patients underwent nipple-sparing mastectomy or skin-sparing mastectomy followed by direct-to-implant or direct-to-expander reconstruction using Serasynth Mesh BR Pocket. The minimum follow-up was 4 weeks.
Results
Of 53 breasts, 44 (83%) required no further surgical intervention, with a mean follow-up of 10 months (range 1-20, mo). Major complications occurred in 9 breasts (17%), and minor complications occurred in 13 (24.5%). Implant loss (13.2%) was primarily due to necrosis (7.5%). A higher body mass index (≥27 kg/m2) and axillary lymph node excision were associated with an increased risk of complications. Notably, 41.9% of patients received adjuvant radiotherapy.
Conclusions
Serasynth Mesh BR Pocket demonstrates a favorable safety profile in prepectoral breast reconstruction, even in a high-risk cohort with substantial radiotherapy exposure. Outcomes are comparable to those of other synthetic meshes, with the added benefit of full resorbability. Careful patient selection, considering body mass index, soft-tissue quality, and lymph node dissection, is essential to optimize results.
DOI
10.1097/gox.0000000000008178
PMID
42903288
Research metadata (titles, abstracts, authors, publication dates) is sourced from Europe PMC, which aggregates content from PubMed/MEDLINE, PubMed Central, and other providers under the U.S. National Library of Medicine (NLM/NCBI). NLM does not claim copyright on abstracts; the original journal publishers or authors may hold rights to the full articles. AI-generated summaries are derived only from the abstract, never the full text, and are always labeled as AI-generated.
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